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Polyclonal Rabbit anti-HDAC7 antibody EMD Millipore #07-937

Product Details

1DB_ID: 1DB-001-0000847474
Company: EMD Millipore
Company product code: 07-937
Product name: Anti-HDAC7
Product type: Primary, Antibody
Size/Price: 100 µL/
Target: HDAC7
Tested applications: WB
Host: Rabbit
Reacts with: Human
Clonality: Polyclonal
Immunogen: Synthetic peptide corresponding to amino acids 164-182 of human HDAC7 [(C)KPKKSLERRKNPLLRKESA].
Specificity: This antibody recognizes human HDAC7. Does not cross-react with HDAC1, HDAC4, or HDAC8.
Storage instructions: Stable for 1 year at 2-8°C from date of receipt.
Species Summary: Reacts with Human. Not tested with other species.
Background: Histone deacetylases (HDAC) are enzymes that regulates transcription by selectively deacetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. Eight members of the HDAC family have been identified, divided in to two classes. Class I includes HDAC-1, 2, 3 and 8 while Class II includes HDAC-4, 5, 6, and 7. Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a C-terminal domain and is dependent on interaction with class I HDACs in the nucleus. It is an active component of different transcriptional co-repressor complexes that can be recruited to specific promoter regions via interactions with transcription factors. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones, resulting in a tighter DNA-histone interaction.
Alternative Names: histone deacetylase 7 , histone deacetylase 7A
Subcategory: Epigenetics & Nuclear Function
Gene ID: NP_001091886.1

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About EMD Millipore

EMD Millipore Bioscience delivers new technologies & workflow solutions that enable researchers to understand complex biological systems & identify new targets.