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Polyclonal Rabbit anti-CREB1 antibody EMD Millipore #06-863

Product Details

1DB_ID: 1DB-001-0000848090
Company: EMD Millipore
Company product code: 06-863
Product name: Anti-CREB
Product type: Primary, Antibody
Size/Price: 200 µg/
Target: CREB1
Tested applications: IP, WB
Host: Rabbit
Reacts with: Human, Mouse
Clonality: Polyclonal
Immunogen: KLH-conjugated, synthetic peptide (CSGAENQ QSGDAAVTEAENQQ) corresponding to a.a. 5-24 of human CREB. The immunizing sequence is identical in pig, shares 19 of 20 residues with mouse and bovine and 18 of 20 residues with rat.
Specificity: This antibody recognizes CREB.
Isotype: IgG
Storage instructions: Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing cap.
Species Summary: Human and mouse. Broad species cross-reactivity expected due to conservation of immunogenic sequence.
Background: CREB is a β-ZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. CREB promotes outgrowth and differentiation as a mediator of Neurotrophin pathways. Additionally, CREB signaling is involved in learning and memory in several organisms. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling.
Alternative Names: active transcription factor CREB, cAMP responsive element binding protein 1, cAMP-response element-binding protein-1, transactivator protein
Subcategory: Epigenetics & Nuclear Function
Gene ID: NM_134442

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Verified publications (26)

Biochim. Biophys. Acta, 2007
The basic helix-loop-helix (bHLH) transcription factor family contains key regulators of cellular proliferation and differentiation as well as the ...
Neuropsychopharmacology, 2011
Systemic administration of amphetamine (AMPH) induces phosphorylation of MeCP2 at Ser421 (pMeCP2) in select populations of neurons in the ...
J. Neurosci., 2011
Brain-derived neurotrophic factor (BDNF) is an important mediator of activity-dependent functions of the nervous system and its expression is ...
J. Endocrinol., 2011
Androgens are the primary regulators of epididymal structure and functions. In the classical view of androgen action, binding of androgen to the ...
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About EMD Millipore

EMD Millipore Bioscience delivers new technologies & workflow solutions that enable researchers to understand complex biological systems & identify new targets.