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Polyclonal Rabbit anti-CASP9 antibody EMD Millipore #AB16969

Product Details

1DB_ID: 1DB-001-0000848175
Company: EMD Millipore
Company product code: AB16969
Product name: Anti-Caspase 9, proform & lg. subunit
Product type: Primary, Antibody
Size/Price: 100 µg/
Target: CASP9
Tested applications: WB
Host: Rabbit
Reacts with: Human, Mouse
Clonality: Polyclonal
Immunogen: Synthetic peptide corresponding to amino acids 41-56 of human caspase-9 (Duan et al. 1996; Srinivasula et al. 1996; Nijhawan et al. 1997). Recognizes proform (46 kDa); sequence analysis predicts cross-reactivity with mouse caspase-9 (>90%).
Specificity: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3 (Duan et al. 1996; Srinivasula et al. 1996; Nijhawan et al. 1997). Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation (Nijhawan et al. 1997). Caspase-9 is also activated by granzyme B and CPP32 (Duan et al. 1996; Srinivasula et al. 1996). Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (Nijhawan et al. 1997). Caspase-9 plays a central role in cell death induced by a wide variety of apoptosis inducers including TNF-alpha, TRAIL, anti-CD-95, FADD, and TRADD (Pan et al. 1998). Caspase-9 is expressed in a variety of human tissues (Duan et al. 1996; Srinivasula et al. 1996).
Storage instructions: The undiluted antibody solution is stable for approximately 6 months when stored 2-8°C.
Alternative Names: ICE-LAP6, Mch-6, Apaf-3
Subcategory: Apoptosis & Cancer
Gene ID: NM_001229.2, NM_032996.1

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Verified publications (2)

Biochemistry, 2011
Mitochondrial-nuclear communication is critical for maintaining mitochondrial activity under stress conditions. Adaptation of the ...
J. Neurosci., 2008
Alzheimer's disease (AD) is characterized by the accumulation of plaques containing beta-amyloid (Abeta) and neurofibrillary tangles (NFTs) consisting...
See all publications

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About EMD Millipore

EMD Millipore Bioscience delivers new technologies & workflow solutions that enable researchers to understand complex biological systems & identify new targets.