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Monoclonal Mouse anti-CREB1 antibody EMD Millipore #05-807

Product Details

1DB_ID: 1DB-001-0000850442
Company: EMD Millipore
Company product code: 05-807
Product name: Anti-phospho-CREB (Ser133), clone 634-2
Product type: Primary, Antibody
Size/Price: 200 µg/
Target: CREB1
clone: 634-2
Tested applications: ICC, IF, WB
Host: Mouse
Reacts with: Mouse, Rat
Clonality: Monoclonal
Immunogen: A proprietary immunogen based on the amino acid sequence containing phospho-serine corresponding to residue 133 of human CREB.
Specificity: Phospho-CREB (Ser133).
Isotype: IgG1
Fraction: Kappa
Storage instructions: Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Species Summary: Mouse and rat. Broad species cross-reactivity expected, based on sequence homology.
Background: CREB is a β ZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. Additionally, CREB signaling is involved in learning and memory in several organisms. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV and MAPKAPK-2.
Alternative Names: active transcription factor CREB, cAMP responsive element binding protein 1, cAMP-response element-binding protein-1, transactivator protein
Subcategory: Epigenetics & Nuclear Function
Gene ID: NM_134442

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Verified publications (1)

Mol. Endocrinol., 2008
Although FSH plays an essential role in controlling gametogenesis, the biology of FSHbeta transcription remains poorly understood, but is known to ...
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About EMD Millipore

EMD Millipore Bioscience delivers new technologies & workflow solutions that enable researchers to understand complex biological systems & identify new targets.